pentobarbital will reduce the extent or result of voriconazole by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unfamiliar.pentobarbital will reduce the extent or influence of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Double brexpiprazole dose around one-two months